Here's a quote I randomly found on the web (http://www.cancer.gov/aboutnci/ncicancerbulletin/archive/2006/062706/page4)
"The definition of metronomic chemotherapy varies, but generally it refers to repetitive, low doses of chemotherapy drugs designed to minimize toxicity and target the endothelium or tumor stroma as opposed to targeting the tumor," says Dr. Harold J. Burstein of the Dana-Farber Cancer Institute, who has led several early-stage trials of metronomic chemotherapy in women with breast cancer."
Anyways, the doctor wanted to see if we parents were open to more chemo. She wanted to use a drug that targets cell development (as opposed to the cis-retinoic acid that allows the cells to develop, but forces them to stop dividing because they "mature.") She had spoken with other doctors and felt like it was a good option for Rene, even though it's only in a trial phase for neuroblastoma treatment.
Unfortunately, Rene already has long-term risk factors from the chemotherapy because he's already been treated with high doses of the same chemical. So there's really no reason not to do it.
As the mom reading between the lines it's scary. This disease is almost impossible to eradicate once it goes to stage IV. The doctor doesn't say that because she's not trying to scare us. But I'm can still see it. Meanwhile, I'm grateful Rene has such a dedicated, experienced, intelligent oncologist and that she actively uses her team members. That's a lot of experience and knowledge on Rene's side. I'm confident that Rene has what it takes to be one of the rare few children who beat stage IV neuroblastoma and live to become adults.